Date of Award
Doctor of Philosophy
Karyn M. Frick, Fred J. Helmstetter, John R. Mantsch, James R. Moyer, Devin Mueller
Beta Adrenergic Receptor, Cocaine, Memory, Propranolol, Reconsolidation, Retrieval
Abnormally strong memories underlie common disorders including addiction and post-traumatic stress disorder (PTSD). Memory disruption would therefore be beneficial for treatment of these disorders. Evidence reveals that cocaine conditioned place preference (CPP) memories are susceptible to long-lasting disruption during memory retrieval. For example, inhibition of β-adrenergic receptor (β-AR) activity within the prelimbic medial prefrontal cortex (PL-mPFC) prevents cocaine CPP memory retrieval, and this retrieval impairment is both long-lasting and prevents subsequent reinstatement of the CPP. Despite this, whether PL-mPFC β-AR activity is a fundamental mechanism required to maintain retrieval of other memories is unclear. Furthermore, how PL-mPFC β-AR activity maintains memory retrieval is unknown. Thus, here I use a combination of behavioral and electrophysiological techniques to 1) evaluate how PL-mPFC β-AR activity regulates retrieval of memories related to a natural reward and to an aversive stimulus and 2) to determine the mechanism of memory retrieval deficits.
Otis, James, "Memory Retrieval Is Maintained By Intrinsic and Synaptic Plasticity in Prelimbic Cortex" (2014). Theses and Dissertations. 744.