Event Title

In Vivo Testing of H2O2 Activated Arylboronate Cancer Drug

Mentor 1

Xiaohua Peng

Location

Union Wisconsin Room

Start Date

28-4-2017 1:30 PM

End Date

28-4-2017 4:00 PM

Description

Toxicity of cancer treatments have been a major concern to cancer patients and physicians. Targeted therapies need to be created to prevent this toxicity to the patient. Arylboronate compounds with various electron donating substituents and different leaving groups have been synthesized by our lab. These compounds are activated by endogenously generated H2O2 by tumors to form Quinone methides. These compounds are designed to target the tumor and reduce side effects of the chemotherapy. We tested the compound that used OMe as the electron donating group in vivo in nude mice. The mice were injected with the compound five times per week along with control mice being injected with the vehicle. The tumors were measured for size and the mice were weighed once a week This compound was proven very effective in treating the tumors compared to the control sample. The tumor size and weight significantly decreased with no detrimental effect to the mice. The compound tested showed promise for further testing and analysis for possible human application in the future.

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Apr 28th, 1:30 PM Apr 28th, 4:00 PM

In Vivo Testing of H2O2 Activated Arylboronate Cancer Drug

Union Wisconsin Room

Toxicity of cancer treatments have been a major concern to cancer patients and physicians. Targeted therapies need to be created to prevent this toxicity to the patient. Arylboronate compounds with various electron donating substituents and different leaving groups have been synthesized by our lab. These compounds are activated by endogenously generated H2O2 by tumors to form Quinone methides. These compounds are designed to target the tumor and reduce side effects of the chemotherapy. We tested the compound that used OMe as the electron donating group in vivo in nude mice. The mice were injected with the compound five times per week along with control mice being injected with the vehicle. The tumors were measured for size and the mice were weighed once a week This compound was proven very effective in treating the tumors compared to the control sample. The tumor size and weight significantly decreased with no detrimental effect to the mice. The compound tested showed promise for further testing and analysis for possible human application in the future.