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Chemistry Theses and Dissertations

Theses/Dissertations from 2024 2024

Johnson, Leah Elizabeth, Investigating and Supporting the Chemistry-Specific and Academic Literacy of Introductory Chemistry Students

MONDAL, PRITHU, DESIGN AND SYNTHESIS OF ACHIRAL AND CHIRAL GABA RECEPTOR SUBTYPE SELECTIVE LIGANDS FOR THE TREATMENT OF ANXIETY, DEPRESSION AS WELL AS EPILEPSY AND ASTHMA

Saxon, Eron, BORON-BASED THERANOSTICS AND PRODRUGS: DESIGN, SYNTHESIS, MECHANISM AND BIOLOGICAL INVESTIGATION

Theses/Dissertations from 2023 2023

Britt, Nicholas Jacob, Structure-Function Studies of Nitrate Reductase Enzymes

Diawara, Fatoumata, Implementation of Reading Interventions in Introductory Chemistry and Its Impact on Student Performance

Dominguez, Rebecca Adel, Hydrogel and Soluble Polymers to Support Metal Ion Chemosensors

Drena, Alexander Shayne, Impact of the Pre-a Motif on Truncated Hemoglobin N Activity

Grimes, Gabrielle Marie, Addressing Learning Gaps in Acid-Base Chemistry Using Novel Three-Dimensional Models with Learning Module

Lee, Maija, PART 1: SYNTHESIS OF BENZODIAZEPINES AS GABAAR POSITIVE MODULATORS TO TREAT INFLAMMATORY BOWEL DISEASE. PART 2: UNSYMMETRICAL FERROCENE LIGANDS IN PALLADIUM CATALYZED SYNTHESIS USING ARYL HALIDES

Mandella, Victoria Lynn, The Search for the Four-electron Reduced Intermediate in the Cytochrome C Nitrite Reductase (CCNIR) - Catalyzed Reduction of Nitrite

Melkonian, Trevor Robert, Structural and Functional Characterization of Pyridoxal-5’-Phosphate-Dependent L-Arginine Desaturases

Owen, Quintus, Utilizing Fluorescent Nanoscale Particles to Create a Map of the Electric Double Layer

Pandey, Kamal Prasad, Part I Enantiospecific Total Synthesis of Unnatural Enantiomers of C-19 Methylated Sarpagine/Macroline/Ajmaline-Type Biologically Active Indole Alkaloids via the Pictet-Spengler Reaction/Dieckmann Cyclization Process. Part II Design, Synthesis, and Characterization of Novel Gamma-Aminobutyric Acid Type A (GABAA) Receptor Ligands for the Treatment of Neurological Disorders Including Epilepsy, Depr

Rezvanian, Sepideh, DESIGN AND SYNTHESIS OF CHIRAL AND ACHIRAL 2, 3 AND 5 SUBTYPE SELECTIVE GABA(A)REGIC LIGANDS FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS AND DIFFERENT TYPES OF CANCERS

Sharmin, Dishary, DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF GABAAR SUBTYPE SELECTIVE (α6, α2/3, AND α5) LIGANDS TO TREAT MIGRAINE, NEUROPATHIC PAIN, TRIGEMINAL PAIN, TOURETTE SYNDROME, EPILEPSY, ANXIETY AND COGNITIVE DISORDERS AS WELL AS ASTHMA

Webb, Daniel Andrew, PART I: IMPROVEMENTS TO THE SYNTHESIS OF CALCITROIC ACID PART II: SYNTHESIS OF NEW IMIDAZODIAZEPINES TO TARGET NON-CENTRAL NERVOUS SYSTEM GABA(A) RECEPTORS PART III: IMPROVED 2-PYRIDYL REDUCTIVE HOMOCOUPLING REACTION USING BIORENEWABLE SOLVENT CYRENETM (DIHYDROLEVOGLUCOSENONE)

Theses/Dissertations from 2022 2022

Ahmed, Taukir, The Activity of QH II 66 and It’s Analogs in Medulloblastoma, Melanoma and Non-small Cell Lung Cancer Cell Lines.

Alam, Shahama, The Effects of an R103Q Mutation on the Chemical and Physical Properties of the Enzyme Cytochrome C Nitrite Reductase (ccNiR)

Belayet, Jawad Bin, Part I: Development of a Novel, Small-Molecule Histone Deacetylase Inhibitor That Enhances Spatial Memory Formation in Mice Part II: Synthesis and SAR Studies of Novel HDAC Inhibitors on Prostate Cancer Cell Line: Mechanistic Insights Towards Anticancer Activity

Hagemann, Trevor Moss, Guest Host Chemistry Part I: The Synthesis of Metal Selective Sensors Part II: The Synthesis of Antibiotic Precursors and Intermediates

Hussain, Muhammad Nazmul, Study of the Chemical Fabrication Process of NSOM Probes and the Modification of the Probe Surface

Islam, Mohammad Mohiminul, In Vitro and In Vivo Identification and Quantification of Carmofur and 5-Fluorouracil Using Tandem Mass Spectrometry

Mian, Md Yeunus, Design and Synthesis of Chiral and Achiral Benzodiazepines and Imidazodiazepines as Α–subtype Selective Gabaar Positive Modulators to Treat Schistosomiasis, Epilepsy, Asthma and Some Mental Disorders

Rajaratnam, Vilashini, Physicochemical Properties, Pharmacokinetics and Biodistribution of ARM14988, an Acid Ceramidase Inhibitor, and Its Potential as Chemotherapeutic Agent for Glioblastoma

Schreurs, David, Investigation into the Measurement of Student Ability: Refinements, Improvements and Enhanced Understanding of Factors That Influence Performance

Williams, Katryna, Part I: Synthesis of Quinolones for Inhibition of the Β-barrel Assembly Machine in Gram Negative Bacteria; Part II: Synthesis of Azo Dye Sensors for Detection of Metal Ions in Aqueous Environments

Zahn, Nicolas Mark, Development of New Treatments for Asthma and Neuropathic Pain Based on Ɣ-Aminobutyric Acid a Receptor (GABAAR) Ligands

Zaman, Muhammad Asad Uz, Inducible DNA Interstrand Cross-linking Agents: Design, Synthesis, Mechanism, and Biomedical Applications

Zhang, Qi, Photo-Reactivity of Bifunctional Naphthalene Compounds Toward DNA

Theses/Dissertations from 2021 2021

Ahmed Khan, Md Zubair, Approach Toward the Total Synthesis of Some Sarpagine Related Indole Alkaloids: Histrixnine, Gelsempervine A, Gelsempervine B, O-Methylmacusine B & 19,20-Dihydro-O-Methylmacusine B,Design, Synthesis & Biological Study of Some Novel Gamma-Aminobutyric Acid Type (GABAA) Receptor Ligands

Ali, Md Shahnawaz, Chapter 1: Part A: A Unique Approach of Preparing 3,3-Disubstituted Oxindoles from Acyclic Tetrasubstituted Aldehydes: Total Synthesis of (-)-Coerulescine and (-)-Coixspirolactam A, Chapter 1: Part B: Synthetic Scope of Brønsted Acid Catalyzed Reactions of Carbonyl Compounds and Ethyl Diazoacetate,

Arabiyat, Moneer, Construction of Fluorescent Helicase Fusion Proteins for Use in Fret Studies on Helicase Function and Stoichiometry

Badhon, Lamia Tabassum, Structure & Function of Enzymes in Two Uncharacterized Gene Clusters from Pseudomonas Brassicacearum & Streptomyces Griseofuscus

Bialka, Emily, Monitoring of Soil Moisture and Human Breath Using Colorimetric Humidity Sensors

Di Milo, Elliot, Determination of the Metabolism, Distribution, and Concentration of Calcitroic Acid

Jahan, Khorshada, Part I: A Concise Synthesis of Microtubule Inhibitor Tryprostatin A and B and Its Analogs Part II: Brønsted Acid Catalyzed Reactions of Aromatic Ketones with Ethyl Diazoacetate and Its Synthetic Scope

Momtaz, Milad, Functional Material Systems for Stimuli-Responsive Interference Coloration

Mutchie, Tania Roseann, Part I: Development of Small-Molecule-Based Probes for the Vitamin D Receptor; Part II: Development of a Scalable Manufacturing Process for Orcein Dye

Rashid, Farjana, Design and Synthesis of Achiral and Chiral Benzodiazepines and Imidazodiazepines to Modulate the Activity of Gabaa Receptors for the Treatment of Cancer, CNS Disorders and Pain

Roni, Md Shadiqur Rashid, Mass Spectrometry Directed Pre-Clinical Studies of Asthma Candidate MIDD0301 and Its Analogs

Virdi, Rajdeep, Protein-Ligand Binding as a Tool to Identify Antiviral Drugs.

Wolters, Kevin, Solid Sorbents for Improved Chemical Separations: Applications in Nuclear Medicine and Environmental Remediation

Theses/Dissertations from 2020 2020

Boscoboinik, Alejandro, Effect of Force and Confinement on Chemical Reaction Kinetics

Campbell, Anahit Marina, Characterization of DNA Interstrand Cross-Linking Agents by Liquid Chromatograhy-Mass Spectrometry

Finn, Garrett Bruce, Novel Approaches to the Determination of Toxic Metals in Industrial Waste and Soil Extracts

Knutson, Daniel E., I. Design and Synthesis of Α6-GABAAR Subtype-selective Pyrazoloquinolinones with Improved Metabolic Stability and Enhanced Bioavailability. II & III. Process Development of Subtype-Selective Α2/3-GABAAR Imidazodiazepines: HZ-166 and KRM-II-81 and Α5-GABAAR Imidazodiazepines: MIDD0301 and GL-II-73

Lund, Eric Daniel, Zinc Proteomics: Interactions of Zn2+, Cd2+, and Metal-binding Ligands with Zn-Binding Sites in the Proteome

Mahim, Afsana, Intracellular Zinc Trafficking: An Interplay of Proteome, Metallothioneine and Glutathione

Rana, Resham, Understanding Mechanochemical Processes on Surfaces Measured in Ultrahigh Vacuum

Salske, Shawn Christopher, Speciation, Transport, and Fate of Heavy Metals in Soils from a Civil War Battlefield: Development of a Novel MAE-GF-AAS Method

SHAHID, SHAHID, A Mechanistic Investigation of Cytochrome C Nitrite Reductase Catalyzed Reduction of Nitrite to Ammonia: The Search for Catalytic Intermediates

Smith, Charles, Fundamental Studies of Trivalent F-Element Separations Using Ionic Liquids and Extraction Chromatography: Toward an Improved Talspeak Process

Thapa, Malati, Development of a Novel Sequential Injection-Proton NMR Method for Determining Cathinones in Forensic Samples

Vuksanovic, Nemanja, Structural and Functional Characterization of L-Enduracididine Biosynthetic Enzymes

Theses/Dissertations from 2019 2019

Ali, Md Mahbbat, Probing the Early Steps in the Catalytic Reduction of Nitrite to Ammonia, Catalyzed By Cytochrome C Nitrite Reductase

Altan, Ali Ihsan, In Situ Chemical Probing of Vacancy Defects in Graphene and Boron Nitride at Room Temperature

Altan, Ali Ihsan, In Situ Chemical Probing of Vacancy Defects in Graphene and Boron Nitride at Room Temperature

Fenske, Tyler G., A Study in Molecular Recognition: Synthesis of a Β-sheet Mimic & Quantitation of Metal Ions in Aqueous Solutions Through Solid Supported Semi-selective Chemosensors

Fisher, Victoria, From General Chemistry to Anatomy and Physiology: Revalidating and Adapting Assessments and Models

Jahan, Rajwana, Part I: Design and Synthesis of Novel Drugs to Treat Asthma By Targeting GABAA Receptors in the Lung Part II: Design and Synthesis of Novel Α2/α3 Subtype Selective GABAAR Ligands for CNS Disorders

Labeots, Joseph Timothy, A Real-Time Approach to Process Monitoring of Heavy Metals: Spectrophotometric Characterization and Application of Novel Azo

Li, Guanguan, Design and Synthesis of Achiral and Chiral Imidazodiazepine (IMDZ) GABA(A)R Subtype Selective Ligands for the Treatment of CNS Disorders, as well as Asthma

Nieman, Amanda Nicole, Targeting the Γ-Aminobutyric Acid a Receptor (gabaar) to Alleviate Inflammation for Asthma and Neuropathic Pain

Olson, Dustin, Chemical Self-Assembly Strategies Toward the Design of Molecular Electronic Circuits

Oyefusi, Adebola, Active Polymeric Materials for 3D Shaping and Sensing

Rahaman, Md Mizzanoor, Part I: A Concise Asymmetric Synthesis of Microtubule Inhibitor Tryprostatin B Part II: Synthesis and Biological Assessment of Histone Deacetylase (HDAC) Inhibitors Part III: Acid Catalyzed Reactions of Aromatic Ketones with Ethyl Diazoacetate

Ray, Atreyei, The Curious Case of NAD-Cleaving Nudix Hydrolases

Udad, Xavier Sacro, Controlling and Manipulating Microscopic Particles in Solution By Using Various Electric Field Geometries

Yu, Olivia B., Part I: An Investigation of Calcitroic Acid and Its Phase II Conjugates. Part II: Toward the Development of a Novel Orally-available Asthma Treatment Targeting Gabaa Receptors in the Lungs

Yu, Olivia B., Part I: an Investigation of Calcitroic Acid and Its Phase II Conjugates. Part II: Toward the Development of a Novel Orally-available Asthma Treatment Targeting Gabaa Receptors in the Lungs

Theses/Dissertations from 2018 2018

Banisadr, Seyedali, New Approaches to Multi-functional Soft Materials

Corby, Megan Josephine, Interactions of Viral and Cellular Helicases

FAN, Heli, Inducible DNA Cross-Linking Agents: Design, Synthesis, Mechanism, and Anticancer Activity

Hoag, Matthew Robert, Renalase as an Intracellular Metabolite Repair Enzyme

Oehm, Sarah Anne, Studies in Molecular Recognition: Non-proteogenic Amino Acids for Antibiotic Studies and Chemosensors for Recognition and Reporting of Metal-ions

Rahman, Md Toufiqur, Shorter and Improved Access to the Key Tetracyclic Core of Sarpagine-Macroline-Ajmaline Indole Alkaloids: the Total Synthesis of Alkaloids Macrocarpines A-g, Talcarpine, N(4)-methyl-n(4),21-secotalpinine, Deoxyperaksine, Dihydroperaksine, Talpinine, O-acetyltalpinine, and N(4)-methyltalpinine

Yerukhimovich, Mark, New Direct Acting Anti-Virals Inhibiting Hepatitis C Virus Helicase and Insights into How ATP Fuels Helicase Action

Theses/Dissertations from 2017 2017

Adams, Heather Loren, Investigation of Tribochemical Reactions Using the Model System of Methyl Thiolate on Copper Foil in Ultrahigh Vacuum and Ab-Initio Calculations

Ahmed, Shamsul Arefin, Short Synthesis and Biological Evaluation of 5-chloro-7-benzoyl 2,3-dihydrobenzo[b]furan -3-carboxylic Acid(brl-37959) and Its Analogs.

Guthrie, Margaret Laurel, Development of Pre-Clinical Assays Based on Tandem Mass Spectrometry to Investigate Gabaa Receptor Modulators

Han, Lanlan, Structure-Function Relationships in Bacterial Regulatory Proteins and an Enzyme Involved in Antibiotic Biosynthesis

McGarry, Jennifer M., Interaction with Nitric Oxide of the Nitrosomonas Europaea Tetraheme Protein Cytochrome C554, and Two of Its Variants, in Increasingly Reducing Environments

Simon, Sandra Maria, A Theoretical Analysis on the Zintl-klemm Concept and Its Extensions

Srinivasan, Shalini, Persistence in STEM: Development of a Persistence Model Integrating Self-efficacy, Outcome Expectations and Performance in Chemistry Gateway Courses

Thuening, Theodore Douglas, Investigation of Catalytic Oxidation and Coupling Reactions on Gold, Palladium, and Gold-palladium Alloys

Tiruveedhula, Veera Venkata Naga Phani Babu, Part – I: Development of a Two-step Regiospecific Synthetic Route for Multigram Scale Synthesis of Β-carboline Analogs for Studies in Primates as Anti-alcohol Agents,part – II: Design and Synthesis of Novel Antimicrobials for the Treatment of Drug Resistant Bacterial Infections Part – Iii: A Novel Synthetic Method for the Synthesis of the Key Quinine Metabolite (3S)-3-Hydroxyquinine

Trate, Jaclyn, Integration of Scale-themed Instruction Across the General Chemistry Curriculum and Selected In-depth Studies

Wankowski, James Lee, Fundamental Studies of Metal Ion Extraction into Ionic Liquids By Macrocyclic Polyethers

Theses/Dissertations from 2016 2016

Abuflaha, Rasha Khaled, Electrical Measurements and Attenuated Total Reflection Infrared Spectroscopic Study of Aromatic Isocyanides and Thiols on Gold

Beaupre, Brett Allen, The Function of Renalase

Cao, Zhe, Encapsulation of Cationic Fluorescent Dyes and Photosensitizers into the Nanoscopic Domains of Poly(ethylene Glycol)-b-poly(ε-caprolactone) Micelles

Hoppe, Robert William, Molecular Recognition in Water: Design, Synthesis, and Characterization of Rigid Molecular Receptors and Enzymatic Mechanistic Probes

Karim, Mohammad Rezaul, The Role of Proteome in Cellular Zn2+ Trafficking and in the Ability of the Fluorescent Zinc Sensors to Image Intracellular Zn2+

Moran, Bradley Michael, Experimental Methods in Cryogenic Spectroscopy: Stark Effect Measurements in Substituted Myoglobin

Mueller, Lisa, Structural and Functional Characterization of Acetoacetate Decarboxylase-Like Enzymes

Omolabake, Surajudeen, The Synthesis of Fluorescent 3, 6-dihydroxyxanthones: A Route to Substituted Fluoresceins

Poe, Michael M., Synthesis of Subtype Selective Bz/GABAA Receptor Ligands for the Treatment of Anxiety, Epilepsy and Neuropathic Pain, as Well as Schizophrenia and Asthma

Schmeling, Ryan, Variable Pathlength Cavity Spectroscopy Development of an Automated Prototype

Witzigmann, Christopher Michael, Part 1: Design, Synthesis, and Evaluation of Novel Gram-positive Antibiotics Part 2: Synthesis of Dihydrobenzofurans Via a New Transition Metal Catalyzed Reaction Part 3: Design, Synthesis, and Evaluation of Bz/gabaa Α6 Positive Allosteric Modulators

Yuan, Nina Yina, Development of Cellular High Throughput Assays to Determine the Electrophysiological Profile of GABA(A) Receptor Modulators for Neurology and Immunology