Follow

Theses/Dissertations from 2020

PDF

Knutson, Daniel E., I. Design and Synthesis of Α6-GABAAR Subtype-selective Pyrazoloquinolinones with Improved Metabolic Stability and Enhanced Bioavailability. II & III. Process Development of Subtype-Selective Α2/3-GABAAR Imidazodiazepines: HZ-166 and KRM-II-81 and Α5-GABAAR Imidazodiazepines: MIDD0301 and GL-II-73

PDF

Lund, Eric Daniel, Zinc Proteomics: Interactions of Zn2+, Cd2+, and Metal-binding Ligands with Zn-Binding Sites in the Proteome

PDF

Mahim, Afsana, Intracellular Zinc Trafficking: An Interplay of Proteome, Metallothioneine and Glutathione

PDF

Smith, Charles, Fundamental Studies of Trivalent F-Element Separations Using Ionic Liquids and Extraction Chromatography: Toward an Improved Talspeak Process

Theses/Dissertations from 2019

PDF

Ali, Md Mahbbat, Probing the Early Steps in the Catalytic Reduction of Nitrite to Ammonia, Catalyzed By Cytochrome C Nitrite Reductase

PDF

Altan, Ali Ihsan, In Situ Chemical Probing of Vacancy Defects in Graphene and Boron Nitride at Room Temperature

PDF

Altan, Ali Ihsan, In Situ Chemical Probing of Vacancy Defects in Graphene and Boron Nitride at Room Temperature

PDF

Fenske, Tyler G., A Study in Molecular Recognition: Synthesis of a Β-sheet Mimic & Quantitation of Metal Ions in Aqueous Solutions Through Solid Supported Semi-selective Chemosensors

PDF

Fisher, Victoria, From General Chemistry to Anatomy and Physiology: Revalidating and Adapting Assessments and Models

PDF

Jahan, Rajwana, Part I: Design and Synthesis of Novel Drugs to Treat Asthma By Targeting GABAA Receptors in the Lung Part II: Design and Synthesis of Novel Α2/α3 Subtype Selective GABAAR Ligands for CNS Disorders

PDF

Labeots, Joseph Timothy, A Real-Time Approach to Process Monitoring of Heavy Metals: Spectrophotometric Characterization and Application of Novel Azo

PDF

Li, Guanguan, Design and Synthesis of Achiral and Chiral Imidazodiazepine (IMDZ) GABA(A)R Subtype Selective Ligands for the Treatment of CNS Disorders, as well as Asthma

PDF

Nieman, Amanda Nicole, Targeting the Γ-Aminobutyric Acid a Receptor (gabaar) to Alleviate Inflammation for Asthma and Neuropathic Pain

PDF

Olson, Dustin, Chemical Self-Assembly Strategies Toward the Design of Molecular Electronic Circuits

PDF

Oyefusi, Adebola, Active Polymeric Materials for 3D Shaping and Sensing

PDF

Rahaman, Md Mizzanoor, Part I: A Concise Asymmetric Synthesis of Microtubule Inhibitor Tryprostatin B Part II: Synthesis and Biological Assessment of Histone Deacetylase (HDAC) Inhibitors Part III: Acid Catalyzed Reactions of Aromatic Ketones with Ethyl Diazoacetate

PDF

Ray, Atreyei, The Curious Case of NAD-Cleaving Nudix Hydrolases

PDF

Udad, Xavier Sacro, Controlling and Manipulating Microscopic Particles in Solution By Using Various Electric Field Geometries

PDF

Yu, Olivia B., Part I: An Investigation of Calcitroic Acid and Its Phase II Conjugates. Part II: Toward the Development of a Novel Orally-available Asthma Treatment Targeting Gabaa Receptors in the Lungs

PDF

Yu, Olivia B., Part I: an Investigation of Calcitroic Acid and Its Phase II Conjugates. Part II: Toward the Development of a Novel Orally-available Asthma Treatment Targeting Gabaa Receptors in the Lungs

Theses/Dissertations from 2018

PDF

Banisadr, Seyedali, New Approaches to Multi-functional Soft Materials

PDF

Corby, Megan Josephine, Interactions of Viral and Cellular Helicases

PDF

FAN, Heli, Inducible DNA Cross-Linking Agents: Design, Synthesis, Mechanism, and Anticancer Activity

PDF

Hoag, Matthew Robert, Renalase as an Intracellular Metabolite Repair Enzyme

PDF

Oehm, Sarah Anne, Studies in Molecular Recognition: Non-proteogenic Amino Acids for Antibiotic Studies and Chemosensors for Recognition and Reporting of Metal-ions

PDF

Rahman, Md Toufiqur, Shorter and Improved Access to the Key Tetracyclic Core of Sarpagine-Macroline-Ajmaline Indole Alkaloids: the Total Synthesis of Alkaloids Macrocarpines A-g, Talcarpine, N(4)-methyl-n(4),21-secotalpinine, Deoxyperaksine, Dihydroperaksine, Talpinine, O-acetyltalpinine, and N(4)-methyltalpinine

PDF

Yerukhimovich, Mark, New Direct Acting Anti-Virals Inhibiting Hepatitis C Virus Helicase and Insights into How ATP Fuels Helicase Action

Theses/Dissertations from 2017

PDF

Adams, Heather Loren, Investigation of Tribochemical Reactions Using the Model System of Methyl Thiolate on Copper Foil in Ultrahigh Vacuum and Ab-Initio Calculations

PDF

Ahmed, Shamsul Arefin, Short Synthesis and Biological Evaluation of 5-chloro-7-benzoyl 2,3-dihydrobenzo[b]furan -3-carboxylic Acid(brl-37959) and Its Analogs.

PDF

Guthrie, Margaret Laurel, Development of Pre-Clinical Assays Based on Tandem Mass Spectrometry to Investigate Gabaa Receptor Modulators

PDF

Han, Lanlan, Structure-Function Relationships in Bacterial Regulatory Proteins and an Enzyme Involved in Antibiotic Biosynthesis

PDF

McGarry, Jennifer M., Interaction with Nitric Oxide of the Nitrosomonas Europaea Tetraheme Protein Cytochrome C554, and Two of Its Variants, in Increasingly Reducing Environments

PDF

Simon, Sandra Maria, A Theoretical Analysis on the Zintl-klemm Concept and Its Extensions

PDF

Srinivasan, Shalini, Persistence in STEM: Development of a Persistence Model Integrating Self-efficacy, Outcome Expectations and Performance in Chemistry Gateway Courses

PDF

Thuening, Theodore Douglas, Investigation of Catalytic Oxidation and Coupling Reactions on Gold, Palladium, and Gold-palladium Alloys

PDF

Tiruveedhula, Veera Venkata Naga Phani Babu, Part – I: Development of a Two-step Regiospecific Synthetic Route for Multigram Scale Synthesis of Β-carboline Analogs for Studies in Primates as Anti-alcohol Agents,part – II: Design and Synthesis of Novel Antimicrobials for the Treatment of Drug Resistant Bacterial Infections Part – Iii: A Novel Synthetic Method for the Synthesis of the Key Quinine Metabolite (3S)-3-Hydroxyquinine

PDF

Trate, Jaclyn, Integration of Scale-themed Instruction Across the General Chemistry Curriculum and Selected In-depth Studies

PDF

Wankowski, James Lee, Fundamental Studies of Metal Ion Extraction into Ionic Liquids By Macrocyclic Polyethers

Theses/Dissertations from 2016

PDF

Abuflaha, Rasha Khaled, Electrical Measurements and Attenuated Total Reflection Infrared Spectroscopic Study of Aromatic Isocyanides and Thiols on Gold

PDF

Beaupre, Brett Allen, The Function of Renalase

PDF

Cao, Zhe, Encapsulation of Cationic Fluorescent Dyes and Photosensitizers into the Nanoscopic Domains of Poly(ethylene Glycol)-b-poly(ε-caprolactone) Micelles

PDF

Hoppe, Robert William, Molecular Recognition in Water: Design, Synthesis, and Characterization of Rigid Molecular Receptors and Enzymatic Mechanistic Probes

PDF

Karim, Mohammad Rezaul, The Role of Proteome in Cellular Zn2+ Trafficking and in the Ability of the Fluorescent Zinc Sensors to Image Intracellular Zn2+

PDF

Moran, Bradley Michael, Experimental Methods in Cryogenic Spectroscopy: Stark Effect Measurements in Substituted Myoglobin

PDF

Mueller, Lisa, Structural and Functional Characterization of Acetoacetate Decarboxylase-Like Enzymes

PDF

Omolabake, Surajudeen, The Synthesis of Fluorescent 3, 6-dihydroxyxanthones: A Route to Substituted Fluoresceins

PDF

Poe, Michael M., Synthesis of Subtype Selective Bz/GABAA Receptor Ligands for the Treatment of Anxiety, Epilepsy and Neuropathic Pain, as Well as Schizophrenia and Asthma

PDF

Schmeling, Ryan, Variable Pathlength Cavity Spectroscopy Development of an Automated Prototype

PDF

Witzigmann, Christopher Michael, Part 1: Design, Synthesis, and Evaluation of Novel Gram-positive Antibiotics Part 2: Synthesis of Dihydrobenzofurans Via a New Transition Metal Catalyzed Reaction Part 3: Design, Synthesis, and Evaluation of Bz/gabaa Α6 Positive Allosteric Modulators

PDF

Yuan, Nina Yina, Development of Cellular High Throughput Assays to Determine the Electrophysiological Profile of GABA(A) Receptor Modulators for Neurology and Immunology

Theses/Dissertations from 2015

PDF

Asad, Md. Sharif Al, Asymmetric Synthesis of All-Carbon α-aryl Quaternary Carbonyl Compounds By Palladium-catalyzed Asymmetric Allylic Alkylation (Pd-AAA) and Their Application to the Synthesis of Biologically Important 3,3′-disubstituted Oxindole and α-disubstituted Quaternary β-lactone Frameworks

PDF

Fatema, Kaniz, Reaction of Zinc Proteome with Biologically Important Metal Binding Ligands

PDF

Fonseca Cabrera, German Oscar, Enantiospecific Stereospecific Strategy for the Total Synthesis of Sarpagine and Macroline Related Oxindole Alkaloids: First Total Synthesis of Affinisine Oxindole, Isoalstonisine, Alstofoline, Macrogentine, N(1)-demethylalstonisine, Alstonoxine A and Second Generation Synthesis of Alstonisine

PDF

Huisman, Matthew, Asymmetric Synthesis of Tryptophan Driviatives and Its Application to Streamlined Synthesis of Tryprosatain A and B

PDF

Koebke, Karl Joseph, Mechanistic Study of Heme Protein-Mediated Nitric Oxide Dioxygenation Using Photolytically Produced Nitric Oxide

PDF

Mahapatra, Mausumi, Chiral Modification of the Pd(111) Surface By Small Organic Molecules

PDF

Momen, Abdul, Improved Extraction Chromatographic Materials for the Separation and Preconcentration of Metal Ions

PDF

Sun, Huabing, Application of Coumarin Derivatives in DNA-associated Study: Mutation Detection, Site-Specific Labeling, Photoinduced Interstrand Cross-Links and Ligation Reactions

PDF

Teske, Kelly Ann, Part I. The Development of Non-secosteroidal Vitamin D Receptor Modulators Part II. The Development of a Universal GTP-ase Assay

PDF

Uddin, Md Nazim, I. Palladium (0)-Catalyzed Asymmetric Rearrangement of Allyl Enol Ether for the Synthesis of Α -aryl Quaternary Carbon Center. II. Synthesis of Chiral Tryptophan Analogs and Studies Towards Synthesis of Tryprostatin A and B

PDF

Wagie, Hannah Elizabeth, Porphyrin as a Spectroscopic Probe of Net Electric Fields in Heme Proteins

PDF

Wang, Yibin, Arylboronates as H2O2 or Photo-Inducible DNA Cross-Linking Agents: Design, Synthesis, Mechanism, and Anticancer Activity

Theses/Dissertations from 2014

PDF

Ababneh, Taher, Design and Implementation of a Near-field Scanning Optical Module for Inverted Microscopes

PDF

Amin, Alaknanda, Microfluidic Device Integration of Electrostatic Corral Trapping Systems

PDF

Biawat, Poonam, The Synthesis of Alpha 5 Subtype Selective GABA(A) /Benzodiazepine Receptors Ligands

PDF

Feleke, Belaynesh, The Development of VDR-coactivator Inhibitors and Their Evaluation Using Biochemical and Cell-based Assays

PDF

Haque, Mohammad Mojibul, Modification of Pyrimidine and Purine Nucleotides By "Click" Chemistry: Design, Synthesis and Properties Study

PDF

Kestell, John, The Surface Chemistry of Adatom Mediated Oligomers of Aromatic Diisocyanides and Dithiols on Au(111) and Granular Films

PDF

Marco Alvarez, Veronica Maria, Development of Novel Methods for Characterization of Complex Organic Mixtures By Liquid Chromatography and Raman Spectroscopy

PDF

Namdarghanbari, Mohammad Ali, Cellular Zinc Trafficking: the Zinc Proteome and Its Reactions with Cadmium

PDF

Oplawski, Sarah, Extraction of Indicator Dyes into Imidazolium-Based Ionic Liquids

PDF

Pawlak, Alan, Crown Ether Stereoisomerism: Implications in Metal Ion Extraction and Ionic Liquid Design

PDF

Shah, Dhara D., Mechanism of the Hydroxylation Reactions Catalyzed By 4-Hydroxyphenylpyruvate Dioxygenase and Hydroxymandelate Synthase

PDF

Shteynbuk, Maria Shevyrev, Part I: Studies Towards Asymmetric α-halogenation and Mechanistic Studies of the Acrylate System with Organocatalyst and Part Ii: Synthesis of α-aryl Quaternary Carbon Centers

PDF

Ulicki, Joseph Steve, Part I: Synthesis and Biological Evaluations of Potent Class L Selective Histone Deacetylase Inhibitors Part II: Aqueous Complexes for Efficient Sizebased Separation of Americium from Curium Part III: Designing Strong Chiral Bronsted Acids and Their Application for Oxaxinanones Derivatization and the Aza-henry Reaction

Theses/Dissertations from 2013

PDF

Alberch, Eduardo, I. Studies on the Organocatalytic Formation of Quaternary Stereocenters. II. Studies on the Claisen Rearrangement as a Route to Quaternary Stereocenters. III. Asymmetric Synthesis of Aldehydes Bearing Quaternary Carbon Centers via the Decarboxylative Asymmetric Allylic Alkylation

PDF

Baranowski, Athena Marie, Evaluation of Vdr-coactivator Inhibitors Using Biochemical and Cell-based Assays

PDF

Garvey, Michael, Applying Computational Methods to Interpret Experimental Results in Tribology and Enantioselective Catalysis

PDF

Garvey, Sarah Lynn, Anion Effects in the Extraction of Metal Ions into Room-Temperature Ionic Liquids (RTILS)

PDF

Grant, April, Characterization of the Distribution, Abundance, and Fate of Metals in Sediment

PDF

Kendhammer, Lisa Kay, Studies in Analytical Chemistry and Chemical Education. Part 1: Characterization of Complex Organics By Raman Spectroscopy and Gas Chromatography. Part 2: Differential Item Functioning on Multiple-choice General Chemistry Assessments

PDF

Kohlmeyer, Ryan R., Functional Organic Nanomaterials

PDF

Kopitzke, Steven, An Optical-Fiber Based Sensor Array for the Simultaneous Analysis of Zinc and Copper in Aqueous Environments

PDF

McCallum, Megan Marie, High-Throughput Approaches for the Assessment of Factors Influencing Bioavailability of Small Molecules in Pre-Clinical Drug Development

PDF

Moua, Maika, Infrared Light Induced Bending of Liquid Crystalline Elastomer Composite-Silicone Bilayer Films

PDF

Nowakowski, Andrew, Zinc Chemical Biology: The Pursuit of the Intracellular Targets of Zinquin

PDF

Wobig, William John, Methods in Metallomics, Proteomics, and Toxicology: Development and Applications of Laser Ablation Inductively Coupled Plasma Mass Spectrometry and Native SDS-PAGE

PDF

Youngblut, Matthew David, Towards the Use of Time-Resolved X-ray Crystallography in Mechanistic Studies of Cytochrome c Nitrite Reductase from Shewanella Oneidensis

Theses/Dissertations from 2012

PDF

Gerlach, Karrie Linn, The Measure and Instruction of Scale in Introductory Chemistry

PDF

Hawkins, Cory, Fundamental and Applied Studies of Metal Ion Extraction by Crown Ethers into Imidazolium-Based Room Temperature Ionic Liquids

PDF

Johnson II, Edward Merle, Part 1. Design and Synthesis of Cysteine/Cystine Prodrugs and Bioisosteres Including Symmetrical and Unsymmetrical Disulfides Designed to Increase Cystine Levels in the CNS in Order to Drive the Cystine/Glutamate Antiporter: A Novel Treatment for Schizophrenia and Drug Addiction. Part 2. Design and Synthesis of Subtype Selective Ester Bioisosteres of BZR Ligands for Gabaa/Benzodiazepine Receptors to Enhance Metabolic Stability

PDF

O'Connell, Erin Margaret, Rapid Knowledge Assessment (RKA): Assessing Students Content Knowledge Through Rapid, in Class Assessment of Expertise

PDF

Pergande, Melissa Rhea, Mitochondrial Targeting in Photodynamic Therapy. Metabolic and Drug Structure Requirements for Specific Mitochondrial Localization. A Pilot Investigation

PDF

Rallapalli, Sundari K., Part I. The First Enantiospecific, Stereospecific Total Synthesis of the Indole Alkaloid Ervincidine. Part II. The Synthesis of Alpha 5 Subtype Selective Ligands for Gaba(a) /Benzodiazepine Receptors

PDF

Walker, Joshua D., Structure and Chemistry of Model Catalysts in Ultrahigh Vacuum