Development of New Analgesic Drugs
Mentor 1
Mahmun M Hossain
Location
Union Wisconsin Room
Start Date
29-4-2016 1:30 PM
End Date
29-4-2016 3:30 PM
Description
The goal of our project is to synthesize analogs of Advil, a common over-the-counter nonsteroidal anti-inflammatory drug (NSAID); used for reducing inflammation in pain patients. We have synthesized our compound from salicylaldehydes and ethyl diazoacetate in quantitatively high yields in order to examine the biological effects of our compound. Our lab has already published a faster procedural method for synthesizing different analogs of Advil, in which we are able to produce them in only four steps. Industrially made Advil has a para-isobutyl group on the benzene structure and is produced using a six step method, whereas we are synthesizing ours with a para-amino and other related groups on the benzene ring in order to test its use as an analgesic drug. Due to this change in composition we are unsure if our compound could be used for its original function as an NSAID, therefore we will test the compound’s biological effects. In addition, the synthetic compounds will be tested for anti-cancer agents. This project’s results could potentially have a significant impact on a patient’s health by improving the effectiveness of analgesic drugs with low toxicity and could also help us to develop a new anti-cancer drug.
Development of New Analgesic Drugs
Union Wisconsin Room
The goal of our project is to synthesize analogs of Advil, a common over-the-counter nonsteroidal anti-inflammatory drug (NSAID); used for reducing inflammation in pain patients. We have synthesized our compound from salicylaldehydes and ethyl diazoacetate in quantitatively high yields in order to examine the biological effects of our compound. Our lab has already published a faster procedural method for synthesizing different analogs of Advil, in which we are able to produce them in only four steps. Industrially made Advil has a para-isobutyl group on the benzene structure and is produced using a six step method, whereas we are synthesizing ours with a para-amino and other related groups on the benzene ring in order to test its use as an analgesic drug. Due to this change in composition we are unsure if our compound could be used for its original function as an NSAID, therefore we will test the compound’s biological effects. In addition, the synthetic compounds will be tested for anti-cancer agents. This project’s results could potentially have a significant impact on a patient’s health by improving the effectiveness of analgesic drugs with low toxicity and could also help us to develop a new anti-cancer drug.
