In Vivo Testing of H2O2 Activated Arylboronate Cancer Drug
Mentor 1
Xiaohua Peng
Location
Union Wisconsin Room
Start Date
28-4-2017 1:30 PM
End Date
28-4-2017 4:00 PM
Description
Toxicity of cancer treatments have been a major concern to cancer patients and physicians. Targeted therapies need to be created to prevent this toxicity to the patient. Arylboronate compounds with various electron donating substituents and different leaving groups have been synthesized by our lab. These compounds are activated by endogenously generated H2O2 by tumors to form Quinone methides. These compounds are designed to target the tumor and reduce side effects of the chemotherapy. We tested the compound that used OMe as the electron donating group in vivo in nude mice. The mice were injected with the compound five times per week along with control mice being injected with the vehicle. The tumors were measured for size and the mice were weighed once a week This compound was proven very effective in treating the tumors compared to the control sample. The tumor size and weight significantly decreased with no detrimental effect to the mice. The compound tested showed promise for further testing and analysis for possible human application in the future.
In Vivo Testing of H2O2 Activated Arylboronate Cancer Drug
Union Wisconsin Room
Toxicity of cancer treatments have been a major concern to cancer patients and physicians. Targeted therapies need to be created to prevent this toxicity to the patient. Arylboronate compounds with various electron donating substituents and different leaving groups have been synthesized by our lab. These compounds are activated by endogenously generated H2O2 by tumors to form Quinone methides. These compounds are designed to target the tumor and reduce side effects of the chemotherapy. We tested the compound that used OMe as the electron donating group in vivo in nude mice. The mice were injected with the compound five times per week along with control mice being injected with the vehicle. The tumors were measured for size and the mice were weighed once a week This compound was proven very effective in treating the tumors compared to the control sample. The tumor size and weight significantly decreased with no detrimental effect to the mice. The compound tested showed promise for further testing and analysis for possible human application in the future.
