Date of Award

May 2019

Degree Type

Thesis

Degree Name

Master of Science

Department

Psychology

First Advisor

Krista M Lisdahl

Committee Members

Han-Joo Lee, Christine L Larson

Keywords

Adolescents, BOLD Responses, Cannabis Use, Response Inhibition

Abstract

Cannabis use has been associated with increased blood oxygen level dependent (BOLD) responses absent of behavioral deficits during a response inhibition task compared to controls. We investigated whether gender and cannabis use result in differences in BOLD responses and behavioral performance during a Go-NoGo task. Participants included eighty-three 16-26 year olds (MJ=36, Controls=46). An emotion based Go-NoGo task required participants to inhibit their response during a “neutral” face. A whole-brain analysis looked at differences between cannabis group, gender, and their interaction. Significant increased BOLD responses were observed in cannabis users compared to controls in the left frontal cortex, left cingulate cortex, and the left thalamus during correct response inhibitions. There were no significant differences on task performance or group by gender interactions. Supporting previous research, cannabis users showed increased BOLD responses in core areas associated with response inhibition during a Go-NoGo task further elucidating the relationships between cannabis and brain-behavior.

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