Towards the Synthesis of an Intrinsic Fluorescent Ligand for the Vitamin D Receptor
Mentor 1
Alexander Arnold
Location
Union Wisconsin Room
Start Date
5-4-2019 1:30 PM
End Date
5-4-2019 3:30 PM
Description
The vitamin D receptor (VDR) is a nuclear hormone receptor that regulates cell proliferation, cell differentiation, and calcium homeostasis. VDR is a transcription factor that can be found in the cytosol and the nuclei. Upon binding to 1,25dihydroxyvitamin D (calcitriol) and other vitamin D active metabolites, VDR localizes in the nuclei where it interacts with coregulators (coactivator and repressor) and DNA. Universal tool compounds to further elucidate the expression and localization of VDR are not available. Therefore, an intrinsic fluorescent VDR ligand will be synthesized to produce the expression and location of VDR in vitro and in vivo. Here, we present the first part of the synthesis of the ligand.
Towards the Synthesis of an Intrinsic Fluorescent Ligand for the Vitamin D Receptor
Union Wisconsin Room
The vitamin D receptor (VDR) is a nuclear hormone receptor that regulates cell proliferation, cell differentiation, and calcium homeostasis. VDR is a transcription factor that can be found in the cytosol and the nuclei. Upon binding to 1,25dihydroxyvitamin D (calcitriol) and other vitamin D active metabolites, VDR localizes in the nuclei where it interacts with coregulators (coactivator and repressor) and DNA. Universal tool compounds to further elucidate the expression and localization of VDR are not available. Therefore, an intrinsic fluorescent VDR ligand will be synthesized to produce the expression and location of VDR in vitro and in vivo. Here, we present the first part of the synthesis of the ligand.
