Analysis of Phosphoinositide 3 (PI3) Kinase Gene and Protein
Mentor 1
Madhusan Dey
Location
Union Wisconsin Room
Start Date
27-4-2018 1:00 PM
Description
Hamzah Hamdan and Madhusudan Dey
hzhamdan@uwm.edu and deym@uwm.edu
Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI
Phosphoinositide 3 (PI3) kinase phosphorylates the 3’-hydroxyl group of the inositol ring of the lipid phosphatidylinositol. 3’-phosphorylated inositol lipid functions as a secondary messenger by interacting with many other cellular proteins that control multiple cellular processes, including cell growth, survival, and motility. Humans and yeast share a common isoform of the PI3 kinase which is known as Vps34. Here, I analyzed the gene and proteins sequences of Vps34 gene and its encoded protein sequence. My studies will help identify the important determinants in PI3K protein that contribute to its biological function, which will ultimately provide insights into how PI3K impacts on development of many human diseases, including lymphoma, immunodeficiency due to hyperactive PI3 kinase, and insulin resistance due to its role in autophagy.
Analysis of Phosphoinositide 3 (PI3) Kinase Gene and Protein
Union Wisconsin Room
Hamzah Hamdan and Madhusudan Dey
hzhamdan@uwm.edu and deym@uwm.edu
Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI
Phosphoinositide 3 (PI3) kinase phosphorylates the 3’-hydroxyl group of the inositol ring of the lipid phosphatidylinositol. 3’-phosphorylated inositol lipid functions as a secondary messenger by interacting with many other cellular proteins that control multiple cellular processes, including cell growth, survival, and motility. Humans and yeast share a common isoform of the PI3 kinase which is known as Vps34. Here, I analyzed the gene and proteins sequences of Vps34 gene and its encoded protein sequence. My studies will help identify the important determinants in PI3K protein that contribute to its biological function, which will ultimately provide insights into how PI3K impacts on development of many human diseases, including lymphoma, immunodeficiency due to hyperactive PI3 kinase, and insulin resistance due to its role in autophagy.
